Meta- and pooled analyses of the effect of glutathione S-transferase M1 and T1 deficiency on chronic obstructive pulmonary disease
Authors: Hu, G.1; Yao, W.2; Zhou, Y.1; Hu, J.1; Shi, Z.1; Li, B.3; Ran, P.1
Source: The International Journal of Tuberculosis and Lung Disease, Volume 12, Number 12, December 2008 , pp. 1474-1481(8)
Publisher: International Union Against Tuberculosis and Lung Disease
Abstract:
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a complex polygenic disease in which gene-environment interactions are very important. A number of studies have investigated the genotypes of glutathione S-transferase M1 and T1 (GSTM1 and GSTT1) in relation to COPD susceptibility in different populations. However, the results of individual studies have been inconsistent.
METHODS: To address the inconsistent findings in studies of the association of the polymorphism of the GSTM1 and GSTT1 genes with susceptibility to COPD, we performed a meta-analysis of the published data. We searched the Medline database for case-control studies published from 1966 to July 2008. Data were extracted and pooled, and ORs were calculated with their 95%CIs.
RESULTS: Twelve eligible studies comprising 1697 patients with COPD and 1867 controls were included in the meta-analysis. The pooled result showed that the GSTM1 deficiency was associated with risk of COPD (OR 1.46, 95%CI 1.16-1.83). Subgroup analysis supported the results in smoking and non-Asian populations, but not in Asian populations. The GSTT1 deficiency was not associated with risk of COPD.
CONCLUSIONS: The GSTM1 gene is a genetic contributor to overall COPD susceptibility in non-Asian populations, and the GSTT1 gene is not associated with COPD.
Keywords: COPD; glutathione S-transferase; case-control study; meta-analysis
Document Type: Regular paper
Affiliations: 1: Guangzhou Institute of Respiratory Diseases, State Key Laboratory of Respiratory Diseases, First Affiliated Hospital, Guangzhou Medical College, Guangzhou, Guangdong, China 2: Department of Respiratory Medicine, Affiliated Hospital of Guangdong Medical College, Zhanjiang, China 3: Experimental Medical Research Centre, Guangzhou Medical College, Guangzhou, Guangdong, China
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