Target product profiles for tests for tuberculosis treatment monitoring and optimization
WHO TEAM Global Tuberculosis Programme EDITORS World Health Organization REFERENCE NUMBERS ISBN: 978-92-4-008117-8
To inform the research and development targets for funders and developers, the World Health Organization (WHO) has developed new target product profiles (TPPs) for tests for TB treatment monitoring and optimization.
These TPPs cover desired tests for three different use case scenarios 1) tests that are done at treatment initiation to identify people with TB who require a more intensive TB treatment regimen which may be longer or contain more medicines; 2) tests that are done during treatment to identify patients with a poor response to treatment who might benefit from a different or longer (optimised) TB treatment regimen, adherence support interventions or adjunctive therapies, or undergo further testing (e.g. for drug resistance); and 3) tests done at the presumed end of treatment to identify patients with a poor treatment outcome or who are at risk of early relapse.
The TPPs identify minimum and optimal targets for several characteristics, some of which are common to the three use cases and some of which are unique. WHO will continue its efforts to regularly update this and other profiles as the pipeline evolves.
More info: https://www.who.int/publications/i/item/9789240081178